The Lung Adenocarcinoma Microenvironment Mining and Its Prognostic Merit.

ABSTRACT:

Background

As a common pathological type of lung cancer, lung adenocarcinoma (LUAD) is mainly treated by surgery, chemotherapy, targeted therapy and radiotherapy. Although a relatively mature treatment system has been established, there are few studies on the microenvironment of LUAD.

Material and methods

The immune and stromal scores of patients from the LUAD cohort in the TCGA database were obtained by using ESTIMATE. The relationship of immune and stromal scores with the clinicopathological characteristics and overall survival of LUAD patients was assessed by R. GO, KEGG and Cox regression analyses were employed to analyze intersecting genes and to identify reliable prognostic markers. The identified genes were also analyzed in the GEPIA database to assess their correlati

SUBMITTER: Zhao R 

PROVIDER: S-EPMC7724272 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature