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KMT2A/C mutations function as a potential predictive biomarker for immunotherapy in solid tumors.


ABSTRACT: Epigenetic factors play important roles in tumor immunology. Histone-lysine N-methyltransferase 2 (KMT2) family genes exert histone H3 methylation, but its role in immunotherapy remains unclear. Our study is the first to investigate the correlation between KMT2 gene mutations and the clinical benefit of immune checkpoint inhibitors (ICI) treatment. We firstly collected a primary ICI-treated cohort (n?=?546) and found that patients with KMT2A/C mutations yielded better prognosis in terms of progression-free survival (PFS, Hazard ratio [HR]?=?0.66, P?=?0.002), objective response rate (ORR, 40.9% vs 20.3%, P?

SUBMITTER: Zhang R 

PROVIDER: S-EPMC7724704 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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KMT2A/C mutations function as a potential predictive biomarker for immunotherapy in solid tumors.

Zhang Rui R   Wu Hao-Xiang HX   Xu Ming M   Xie Xiaoyan X  

Biomarker research 20201209 1


Epigenetic factors play important roles in tumor immunology. Histone-lysine N-methyltransferase 2 (KMT2) family genes exert histone H3 methylation, but its role in immunotherapy remains unclear. Our study is the first to investigate the correlation between KMT2 gene mutations and the clinical benefit of immune checkpoint inhibitors (ICI) treatment. We firstly collected a primary ICI-treated cohort (n = 546) and found that patients with KMT2A/C mutations yielded better prognosis in terms of progr  ...[more]

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