Ontology highlight
ABSTRACT:
SUBMITTER: De Ravin SS
PROVIDER: S-EPMC7724899 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
De Ravin Suk See SS Brault Julie J Meis Ronald J RJ Li Linhong L Theobald Narda N Bonifacino Aylin C AC Lei Hong H Liu Taylor Q TQ Koontz Sherry S Corsino Cristina C Zarakas Marissa A MA Desai Jigar V JV Clark Aaron B AB Choi Uimook U Metzger Mark E ME West Kamille K Highfill Steven L SL Kang Elizabeth E Kuhns Douglas B DB Lionakis Michail S MS Stroncek David F DF Dunbar Cynthia E CE Tisdale John F JF Donahue Robert E RE Dahl Gary A GA Malech Harry L HL
Blood advances 20201201 23
Granulocytes from patients with chronic granulomatous disease (CGD) have dysfunctional phagocyte reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase that fails to generate sufficient antimicrobial reactive oxidative species. CGD patients with severe persistent fungal or bacterial infection who do not respond to antibiotic therapy may be given apheresis-derived allogeneic granulocyte transfusions from healthy volunteers to improve clearance of intractable infections. Allogeneic gr ...[more]