Ontology highlight
ABSTRACT:
Methods and analysis: This is a mechanistic clinical trial. 84 women with confirmed ANOCA and 42 aged-matched healthy women (neither angina symptoms nor coronary stenosis) are to be recruited for mental and adenosine vasodilator stress tests. Positron emission tomography CT with ammonia N-13 will be used to evaluate the myocardial perfusion and MBF changes between stress and rest. MSIMI is defined as a summed difference score (SDS) of ?3?and adenosine stress-induced myocardial ischaemia is defined as an SDS of ?4. Other assessments include Reactive Hyperemia Index for microvascular endothelial function, peripheral arterial tonometry or digital vasomotor response, and a series of blood and psychometric tests.
Ethics and dissemination: This mechanistic clinical trial was approved by the Ethics Committee of Guangdong Provincial People's Hospital. Findings will be disseminated through peer-reviewed publications and conference presentations.
Trial registration number: NCT03982901; Pre-results.
SUBMITTER: Ma H
PROVIDER: S-EPMC7725072 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Ma Huan H Guo Lan L Fei Hongwen H Yin Han H Wang Haochen H Bai Bingqing B Liu Yuting Y Wang Shuxia S Geng Qingshan Q Jiang Wei W
BMJ open 20201208 12
<h4>Introduction</h4>Two-thirds of women with symptoms of angina have 'angina with no obstructive coronary artery disease' (ANOCA). Growing evidence supports the use of coronary artery function testing for the diagnosis of ANOCA. Research into the prevalence of mental stress-induced myocardial ischaemia (MSIMI) among women with ANOCA is lacking. MSIMI is common in clinically stable patients with coronary artery disease. It is not associated coronary stenosis but is a prognostic risk factor. Here ...[more]