Vascular Dysfunction, Oxidative Stress, and Inflammation in Chronic Kidney Disease.

ABSTRACT:

Background

Increased arterial stiffness and vascular endothelial dysfunction are important nontraditional cardiovascular risk factors evident in patients with CKD. Vascular oxidative stress and inflammation may contribute to vascular dysfunction in CKD, but direct evidence is lacking.

Methods

We assessed carotid-femoral pulse-wave velocity (arterial stiffness) and brachial artery flow-mediated dilation (vascular endothelial function) in participants with moderate-to-severe CKD (eGFR 15-59 ml/min per 1.73 m²) and in healthy controls. Change in brachial artery flow-mediated dilation after an acute infusion of ascorbic acid to inhibit vascular oxidative stress (versus saline) was also measured. Protein expression of vascular endothelial cells collected from a periphe

SUBMITTER: Nowak KL 

PROVIDER: S-EPMC7725223 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature