In situ forming implants exposed to ultrasound enhance therapeutic efficacy in subcutaneous murine tumors.

ABSTRACT: In situ forming implants (ISFIs) allow for a high initial intratumoral concentration and sustained release of the chemotherapeutic. However, clinical translation is impeded primarily due to limited drug penetration from the tumor/boundary interface and poor intratumoral drug retention. Therapeutic ultrasound (TUS) has become a popular approach for improving drug penetration of transdermal devices and increasing cellular uptake of nanoparticles. These effects are driven by the mechanical and thermal bioeffects associated with TUS. In this study, we characterize the released drug penetration, retention, and overall therapeutic response when exposing ISFI to the combination of the mechanical and thermal effects of TUS (C-TUS). ISFIs were intratumorally injected into subcutaneous murine tumors

SUBMITTER: Jeganathan S 

PROVIDER: S-EPMC7725358 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature