Th17-Immune Response in Patients With Membranous Nephropathy Is Associated With Thrombosis and Relapses.

ABSTRACT: Membranous nephropathy (MN) is a rare autoimmune kidney disease. Most autoimmune diseases are associated with a pro-inflammatory Th17-immune response, but little is known about immune dysregulation in MN. In China, MN was associated with exposure to fine air particulate matter (PM_2.5) that could act as a danger signal and redirect immune response toward the Th2 or Th17 pathway. We aimed to analyze the cytokine profile of MN patients and to study the possible environmental factors involved in this immune reorientation, as well as the consequences on the prognosis of the disease. In this prospective study, 59 MN patients filled a comprehensive lifestyle questionnaire. Peripheral blood cells from MN patients were stimulated in vitro to measure the cytokines produced in super

SUBMITTER: Cremoni M 

PROVIDER: S-EPMC7725714 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature