The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies.
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ABSTRACT:
SUBMITTER: Tuovinen T
PROVIDER: S-EPMC7726142 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies.
Tuovinen Timo T Kananen Janne J Rajna Zalan Z Lieslehto Johannes J Korhonen Vesa V Rytty Riikka R Mattila Heli H Huotari Niko N Raitamaa Lauri L Helakari Heta H Elseoud Ahmed Abou AA Krüger Johanna J LeVan Pierre P Tervonen Osmo O Hennig Juergen J Remes Anne M AM Nedergaard Maiken M Kiviniemi Vesa V
Scientific reports 20201209 1
Biomarkers sensitive to prodromal or early pathophysiological changes in Alzheimer's disease (AD) symptoms could improve disease detection and enable timely interventions. Changes in brain hemodynamics may be associated with the main clinical AD symptoms. To test this possibility, we measured the variability of blood oxygen level-dependent (BOLD) signal in individuals from three independent datasets (totaling 80 AD patients and 90 controls). We detected a replicable increase in brain BOLD signal ...[more]
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