Detection of additional abnormalities or co-morbidities in women with suspected intrahepatic cholestasis of pregnancy.

ABSTRACT:

Background

Current guidelines recommend viral, autoimmune, coagulation and liver ultrasound testing in intrahepatic cholestasis of pregnancy to exclude alternative diagnoses.

Methods

Electronic health records were searched for investigations and diagnoses in women with raised bile acid concentrations (>10 µmol/L) between January 2016 and December 2017 at two UK maternity units.

Results

Five hundred and thirty-one women had a raised bile acid concentration (median (IQR): 18 (13-32 µmol/L)) at a median gestation of 35.1 (IQR 31.8-37.0) weeks. Out of 531 women, 250 (47.1%) had full virology, autoimmune and ultrasound tests, and 348 (65.5%) had coagulation performed. Positive hepatitis B and C results were previously known. No new Epstein-Barr virus, cytomegalovirus or he

SUBMITTER: Conti-Ramsden F 

PROVIDER: S-EPMC7726172 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature