Ontology highlight
ABSTRACT:
SUBMITTER: Sengupta K
PROVIDER: S-EPMC7726560 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Sengupta Kasturi K Loro Emanuele E Khurana Tejvir S TS
Scientific reports 20201209 1
Upregulation of utrophin, a dystrophin related protein, is considered a promising therapeutic approach for Duchenne muscular dystrophy (DMD). Utrophin expression is repressed at the post-transcriptional level by a set of miRNAs, among which let-7c is evolutionarily highly conserved. We designed PMO-based SBOs complementary to the let-7c binding site in UTRN 3'UTR, with the goal of inhibiting let-7c interaction with UTRN mRNA and thus upregulating utrophin. We used the C2C12UTRN5'luc3' reporter c ...[more]