Immunologic Correlates of Pathologic Complete Response to Preoperative Immunotherapy in Hepatocellular Carcinoma.
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ABSTRACT:
SUBMITTER: Kaseb AO
PROVIDER: S-EPMC7726707 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Immunologic Correlates of Pathologic Complete Response to Preoperative Immunotherapy in Hepatocellular Carcinoma.
Kaseb Ahmed Omar AO Vence Luis L Blando Jorge J Yadav Shalini S SS Ikoma Naruhiko N Pestana Roberto Carmagnani RC Vauthey Jean Nicolas JN Allison James P JP Sharma Padmanee P
Cancer immunology research 20190709 9
In hepatocellular carcinoma (HCC), surgical resection is associated with high recurrence rate, and no effective adjuvant therapy currently exists. We initiated a pilot randomized trial of perioperative immunotherapy with nivolumab and ipilimumab for resectable HCC. Here, we provide an illustrative report of a case that achieved a complete response and report immunologic correlates of this complete pathologic response to perioperative immunotherapy. Clinical response was correlated with an increa ...[more]
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