Dataset Information

Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT: Context: Lean body mass is essential for health, yet consensus regarding the effectiveness of protein interventions in increasing lean body mass is lacking.

Objective: The aim of this systematic review was to evaluate the dose-response relationship of the effects of protein intake on lean body mass.

Data sources: The PubMed and Ichushi-Web databases were searched electronically, and reference lists of the literature included here and in other meta-analyses were searched manually.

Study selection: Randomized controlled trials evaluating the effects of protein intake on lean body mass were included.

Data extraction: Two authors independently screened the abstracts; 5 reviewed the full texts.

Results: A total of 5402 study participants from 105 articles were included. In the multivariate spline model, the mean increase in lean body mass associated with an increase in protein intake of 0.1?g/kg of body weight per day was 0.39 kg (95%CI, 0.36-0.41) and 0.12 kg (95%CI, 0.11-0.14) below and above the total protein intake of 1.3?g/kg/d, respectively.

Conclusions: These findings suggest that slightly increasing current protein intake for several months by 0.1?g/kg/d in a dose-dependent manner over a range of doses from 0.5 to 3.5?g/kg/d may increase or maintain lean body mass.

Systematic review registration: UMIN registration number UMIN000039285.

SUBMITTER: Tagawa R

PROVIDER: S-EPMC7727026 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials.

Tagawa Ryoichi R Watanabe Daiki D Ito Kyoko K Ueda Keisuke K Nakayama Kyosuke K Sanbongi Chiaki C Miyachi Motohiko M

Nutrition reviews 20201104

<h4>Context</h4>Lean body mass is essential for health, yet consensus regarding the effectiveness of protein interventions in increasing lean body mass is lacking.<h4>Objective</h4>The aim of this systematic review was to evaluate the dose-response relationship of the effects of protein intake on lean body mass.<h4>Data sources</h4>The PubMed and Ichushi-Web databases were searched electronically, and reference lists of the literature included here and in other meta-analyses were searched manual ...[more]

PMID: 33300582

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Project description:We aimed to investigate whether the use of targeted agents (TAs) in advanced gastroesophageal cancer (GEC) increased the complete response (CR) and to assess the surrogate endpoints for survival in the targeted treatment of GEC by using a meta-analysis of randomized controlled trials (RCTs). Eligible studies were identified using Medline, PubMed, and meeting abstracts. Searches were last updated on April 30, 2018. We calculated the incidence and Peto odds ratio (Peto OR) of CR events in patients assigned to TAs compared with controls. Simple linear regression models were fitted for median overall survival (OS) and each surrogate [median progression-free survival (PFS), CRs, objective response rate (ORR), and disease control rate (DCR), respectively]. A total of 7,892 GEC patients from 18 RCTs were included for analysis. The incidence of CR in GEC patients treated with TAs was 2.0% (95% CI, 1.3%-3.0%) compared with 1.7% (95% CI, 1.0%-2.7%) in the control arms. The use of TAs in advanced GEC had a tendency to improve the possibility of archiving CR (Peto OR 1.42; 95% CI, 0.98-2.04; P=0.064) compared with controls. Subgroup analysis according to treatment TAs showed that the addition of antiepidermal growth factor receptor (EGFR) agents to chemotherapy in GEC significantly improved the CR rate in comparison with control (Peto OR 1.77; 95% CI, 1.02-3.09; P=0.044), but not for other molecular TAs (P=0.49 for angiogenesis inhibitors, P=0.66 for mesenchymal-epithelial transition inhibitors). We also found that the addition of TAs to first-line therapy (Peto OR 1.41; 95% CI, 0.94-2.11; P=0.098) had a tendency to increase the chance of obtaining a CR, but not for second-line therapy (Peto OR 1.47; 95% CI, 0.60-3.55; P=0.40). In addition, correlation analysis indicates that PFS, ORR, and DCR were strongly correlated with OS for GEC patients receiving TAs (r=0.85 for PFS; r=0.86 for ORR; r=0.81 for DCR). No marked correlation was found between OS and CRs (r=0.43; P=0.18). Although the CR is a rate event in advanced GEC patients, adding the TAs to therapies, especially for anti-EGFR agents, increases the chance of archiving CR in comparison with the controls. PFS, ORR, and DCR are significantly correlated with OS and could be used as surrogate endpoints in patients with GEC who have received TA therapy, but not for CR.

Dataset Information

Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials.

Publications

Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials.

Similar Datasets

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