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Preconception air pollution exposure and glucose tolerance in healthy pregnant women in a middle-income country.

ABSTRACT: Background: Preconception exposure to air pollution has been associated with glucose tolerance during pregnancy. However, the evidence in low and middle-income countries (LMICs) is under debate yet. Therefore, this study aimed to assess the relationship between exposure to ambient particulate matter (PM) and traffic indicators with glucose tolerance in healthy pregnant women in Sabzevar, Iran (2019).

Methods: Two-hundred and fifty healthy pregnant women with singleton pregnancies and 24-26?weeks of gestations participated in our study. Land use regression (LUR) models were applied to estimate the annual mean of PM₁, PM_2.5 and PM₁₀ at the residential address. Traffic indicators, including proximity of women to major roads as well as total streets length in 100, 300 and 500?m buffers around the home were calculated using the street map of Sabzevar. The oral glucose tolerance test (OGTT) was used to assess glucose tolerance during pregnancy. Multiple linear regression adjusted for relevant covariates was used to estimate the association of fasting blood glucose (FBG), 1-h and 2-h post-load glucose with PMs and traffic indicators.

Results: Exposure to PM₁, PM_2.5 and PM₁₀ was significantly associated with higher FBG concentration. Higher total streets length in a 100?m buffer was associated with higher FBG and 1-h glucose concentrations. An interquartile range (IQR) increase in proximity to major roads was associated with a decrease of -?3.29?mg/dL (95% confidence interval (CI): -?4.35, -?2.23, P-value
Conclusion: We found that higher preconception exposure to air pollution was associated with higher FBG and 1-h glucose concentrations during pregnancy.

SUBMITTER: Najafi ML

PROVIDER: S-EPMC7727159 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Preconception air pollution exposure and glucose tolerance in healthy pregnant women in a middle-income country.

Najafi Moslem Lari ML Zarei Mehdi M Gohari Ali A Haghighi Leyla L Heydari Hafez H Miri Mohammad M

Environmental health : a global access science source 20201209 1

<h4>Background</h4>Preconception exposure to air pollution has been associated with glucose tolerance during pregnancy. However, the evidence in low and middle-income countries (LMICs) is under debate yet. Therefore, this study aimed to assess the relationship between exposure to ambient particulate matter (PM) and traffic indicators with glucose tolerance in healthy pregnant women in Sabzevar, Iran (2019).<h4>Methods</h4>Two-hundred and fifty healthy pregnant women with singleton pregnancies an ...[more]

PMID: 33298083

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Dataset Information

Preconception air pollution exposure and glucose tolerance in healthy pregnant women in a middle-income country.

Publications

Preconception air pollution exposure and glucose tolerance in healthy pregnant women in a middle-income country.

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