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Common causes and characteristics of adverse drug reactions in older adults: a retrospective study.


ABSTRACT: Background: Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adults (?65?years) in comparison to younger individuals (
Methods: Of 37,523 cases reported at a Korean pharmacovigilance center from 2011 to 2018, we reviewed 18,842 ADRs of certain or probable causality on the basis of WHO-UMC criteria. We estimated the number of ADRs per 1000 patients exposed to the major culprit drugs, and incidence rate ratios were obtained to assess high- and low-risk medications in older adults.

Results: In total, 4152 (22.0%) ADRs were reported for 3437 older adults (mean age, 74.6?years and 57.3% female). Tramadol (rate ratio, 1.32; 95% confidence interval [CI], 1.21-1.44; P?
Conclusion: For early detection of ADRs in older adults, better understanding of differences in the causes and characteristics thereof in comparison to the general population is needed.

SUBMITTER: Woo SD 

PROVIDER: S-EPMC7727226 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Common causes and characteristics of adverse drug reactions in older adults: a retrospective study.

Woo Seong-Dae SD   Yoon Jiwon J   Doo Go-Eun GE   Park Youjin Y   Lee Youngsoo Y   Lee So-Hee SH   Lee Young-Hee YH   Ye Young-Min YM  

BMC pharmacology & toxicology 20201210 1


<h4>Background</h4>Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adults (≥65 years) in comparison to younger individuals (< 65 years).<h4>Methods</h4>Of 37,523 cases reported at a Korean pharmacovigilance center from 2011 to 2018, we reviewed 18,842 ADRs of certain or probable causality on the basis of WHO-UMC criteria. We estimated the nu  ...[more]

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