Ontology highlight
ABSTRACT:
SUBMITTER: Ha K
PROVIDER: S-EPMC7728438 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Ha Kotdaji K Nobuhara Mai M Wang Qinzhe Q Walker Rebecca V RV Qian Feng F Schartner Christoph C Cao Erhu E Delling Markus M
eLife 20201109
Mutations in the polycystin proteins, PC-1 and PC-2, result in autosomal dominant polycystic kidney disease (ADPKD) and ultimately renal failure. PC-1 and PC-2 enrich on primary cilia, where they are thought to form a heteromeric ion channel complex. However, a functional understanding of the putative PC-1/PC-2 polycystin complex is lacking due to technical hurdles in reliably measuring its activity. Here we successfully reconstitute the PC-1/PC-2 complex in the plasma membrane of mammalian cell ...[more]