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ABSTRACT: Background
Hand tremor typically has a negative impact on a person's ability to complete many common daily activities. Previous research has investigated how to quantify hand tremor with smartphones and wearable sensors, mainly under controlled data collection conditions. Solutions for daily real-life settings remain largely underexplored.Objective
Our objective was to monitor and assess hand tremor severity in patients with Parkinson disease (PD), and to better understand the effects of PD medications in a naturalistic environment.Methods
Using the Welch method, we generated periodograms of accelerometer data and computed signal features to compare patients with varying degrees of PD symptoms.Results
We introduced and empirically evaluated the tremor intensity parameter (TIP), an accelerometer-based metric to quantify hand tremor severity in PD using smartphones. There was a statistically significant correlation between the TIP and self-assessed Unified Parkinson Disease Rating Scale (UPDRS) II tremor scores (Kendall rank correlation test: z=30.521, P<.001, ?=0.5367379; n=11). An analysis of the "before" and "after" medication intake conditions identified a significant difference in accelerometer signal characteristics among participants with different levels of rigidity and bradykinesia (Wilcoxon rank sum test, P<.05).Conclusions
Our work demonstrates the potential use of smartphone inertial sensors as a systematic symptom severity assessment mechanism to monitor PD symptoms and to assess medication effectiveness remotely. Our smartphone-based monitoring app may also be relevant for other conditions where hand tremor is a prevalent symptom.
SUBMITTER: Kuosmanen E
PROVIDER: S-EPMC7728543 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Kuosmanen Elina E Wolling Florian F Vega Julio J Kan Valerii V Nishiyama Yuuki Y Harper Simon S Van Laerhoven Kristof K Hosio Simo S Ferreira Denzil D
JMIR mHealth and uHealth 20201126 11
<h4>Background</h4>Hand tremor typically has a negative impact on a person's ability to complete many common daily activities. Previous research has investigated how to quantify hand tremor with smartphones and wearable sensors, mainly under controlled data collection conditions. Solutions for daily real-life settings remain largely underexplored.<h4>Objective</h4>Our objective was to monitor and assess hand tremor severity in patients with Parkinson disease (PD), and to better understand the ef ...[more]