Ontology highlight
ABSTRACT:
SUBMITTER: Liu P
PROVIDER: S-EPMC7728613 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liu Peipei P Pan Zhongzong Z Gu Chunyin C Cao Xiaodan X Liu Xiaowu X Zhang Jianjian J Xiao Zheng Z Wang Xueping X Guo Haibing H Ju Dianwen D Deng Su-Jun SJ
Frontiers in immunology 20201127
The critical role of IgE in allergic diseases is well-documented and clinically proven. Omalizumab, a humanized anti-IgE antibody, was the first approved antibody for the treatment of allergic diseases. Nevertheless, omalizumab still has some limitations, such as product instability and dosage restriction in clinical application. In this study, we attempted to develop an omalizumab biobetter antibody with the potential to overcome its limitations. We removed two aspartic acid isomerization hotsp ...[more]