Ontology highlight
ABSTRACT:
SUBMITTER: Maia J
PROVIDER: S-EPMC7729189 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Maia Joana J Otake Andreia Hanada AH Poças Juliana J Carvalho Ana Sofia AS Beck Hans Christian HC Magalhães Ana A Matthiesen Rune R Strano Moraes Maria Carolina MC Costa-Silva Bruno B
Frontiers in cell and developmental biology 20201127
Pancreatic cancers (PC) are highly metastatic with poor prognosis, mainly due to delayed detection. We previously showed that PC-derived extracellular vesicles (EVs) act on macrophages residing in the liver, eliciting extracellular matrix remodeling in this organ and marked hepatic accumulation of CD11b<sup>+</sup> bone marrow (BM) cells, which support PC liver metastasis. We here show that PC-EVs also bind to CD11b<sup>+</sup> BM cells and induce the expansion of this cell population. Transcrip ...[more]