Ontology highlight
ABSTRACT:
SUBMITTER: Bessa C
PROVIDER: S-EPMC7729450 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Bessa Cláudia C Matos Paulo P Jordan Peter P Gonçalves Vânia V
International journal of molecular sciences 20201127 23
Alternative splicing (AS) is a critical post-transcriptional regulatory mechanism used by more than 95% of transcribed human genes and responsible for structural transcript variation and proteome diversity. In the past decade, genome-wide transcriptome sequencing has revealed that AS is tightly regulated in a tissue- and developmental stage-specific manner, and also frequently dysregulated in multiple human cancer types. It is currently recognized that splicing defects, including genetic alterat ...[more]