Ontology highlight
ABSTRACT:
SUBMITTER: Jordan PM
PROVIDER: S-EPMC7729929 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Jordan Paul M PM Gerstmeier Jana J Pace Simona S Bilancia Rossella R Rao Zhigang Z Börner Friedemann F Miek Laura L Gutiérrez-Gutiérrez Óscar Ó Arakandy Vandana V Rossi Antonietta A Ialenti Armando A González-Estévez Cristina C Löffler Bettina B Tuchscherr Lorena L Serhan Charles N CN Werz Oliver O
Cell reports 20201001 2
Underlying mechanisms of how infectious inflammation is resolved by the host are incompletely understood. One hallmark of inflammation resolution is the activation of specialized pro-resolving mediators (SPMs) that enhance bacterial clearance and promote tissue repair. Here, we reveal α-hemolysin (Hla) from Staphylococcus aureus as a potent elicitor of SPM biosynthesis in human M2-like macrophages and in the mouse peritoneum through selective activation of host 15-lipoxygenase-1 (15-LOX-1). S. a ...[more]