Ontology highlight
ABSTRACT:
SUBMITTER: Tyagi A
PROVIDER: S-EPMC7729981 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20201128 23
Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by the dysfunction of the enzyme phenylalanine hydroxylase (PAH). Alterations in the level of PAH leads to the toxic accumulation of phenylalanine in the blood and brain. Protein degradation mediated by ubiquitination is a principal cellular process for maintaining protein homeostasis. Therefore, it is important to identify the E3 ligases responsible for PAH turnover and proteostasis. Here, we report that anaphase-promotin ...[more]