Ontology highlight
ABSTRACT:
SUBMITTER: Gan BH
PROVIDER: S-EPMC7730455 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Gan Bee-Ha BH Cai Xingguang X Javor Sacha S Köhler Thilo T Reymond Jean-Louis JL
Molecules (Basel, Switzerland) 20201130 23
There is an urgent need to develop new antibiotics against multidrug-resistant bacteria. Many antimicrobial peptides (AMPs) are active against such bacteria and often act by destabilizing membranes, a mechanism that can also be used to permeabilize bacteria to other antibiotics, resulting in synergistic effects. We recently showed that <b>G3KL</b>, an AMP with a multibranched dendritic topology of the peptide chain, permeabilizes the inner and outer membranes of Gram-negative bacteria including ...[more]