Ontology highlight
ABSTRACT:
SUBMITTER: Picarazzi F
PROVIDER: S-EPMC7730706 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Picarazzi Francesca F Vicenti Ilaria I Saladini Francesco F Zazzi Maurizio M Mori Mattia M
Molecules (Basel, Switzerland) 20201203 23
The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral replication process, catalyzing the viral RNA synthesis using a metal ion-dependent mechanism. In recent years, RdRp has emerged as an optimal target for the development of antiviral drugs, as demonstrated by recent approvals of sofosbuvir and remdesivir against Hepatitis C virus (HCV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), respectively. In this work, we overview the main sequence and structur ...[more]