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Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans.

ABSTRACT: Background/aim: Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the association of five SNPs in the IL-10 promoter with clinical features such as Gleason score and smoking.

Materials and methods: A total of 413 DNA samples were obtained from a nested case-control study of African American males who were genotyped for 5 SNPs utilizing pyrosequencing. Multiple and binary logistic regression models were applied to analyze the clinical and genotypic data.

Results: rs12122923 and rs1800871 were associated with PCa risk. Smoking was also found to increase the risk of PCa by 1.6-fold. rs1800893 was found to be associated with lower grades for prostate cancer.

Conclusion: IL-10 promoter polymorphisms might be a risk factor for PCa development in smoking subjects and PCa progression.

SUBMITTER: Abbas M 

PROVIDER: S-EPMC7731238 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans.

Abbas Muneer M   Mason Tshela T   Ibad Aliza A   Khraiwesh Mozna M   Apprey Victor V   Kanaan Yasmine Y   Wilson Bradford B   Dunston Georgia G   Ricks-Santi Luisel L   Brim Hassan H  

Anticancer research 20200101 1

<h4>Background/aim</h4>Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the association of five SNPs in the IL-10 promoter with clinical features such as Gleason score and smoking.<h4>Materials and methods</h4>A total of 413 DNA samples were obtained from a  ...[more]

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