Dataset Information
Interleukin-33 gene polymorphisms and chronic obstructive pulmonary disease in the Chinese Han population.
Ontology highlight
ABSTRACT: Objective
To investigate the relationship between interleukin (IL)-33 gene polymorphisms rs928413 and rs7044343 with chronic obstructive pulmonary disease (COPD) in the Chinese Han population.Method
We assessed IL-33 rs928413 and rs7044343 polymorphisms by Sanger sequencing of PCR products amplified from the genomic DNA of 160 COPD patients and 123 healthy controls.Results
There was no significant difference in the distribution of rs928413 AA, AG, or AA genotypes or rs7044343 CC, CT, or TT genotypes between the two groups. However, COPD patients had a significantly higher frequency of the rs928413 G allele G (14.1% vs 7.3%, respectively). This allele was significantly associated with susceptibility to COPD (odds ratio [OR]: 2.04, 95% confidence interval [CI]: 1.12-3.57). The rs928413 dominant inheritance model was associated with COPD susceptibility (OR: 2.08, 95%CI: 1.09-4.04).Conclusion
The G allele of rs928413 and the rs928413 dominant inheritance model were associated with susceptibility to COPD in the Chinese Han population.
SUBMITTER: Xu X
PROVIDER: S-EPMC7731714 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Interleukin-33 gene polymorphisms and chronic obstructive pulmonary disease in the Chinese Han population.
The Journal of international medical research 20201201 12
<h4>Objective</h4>To investigate the relationship between interleukin (IL)-33 gene polymorphisms rs928413 and rs7044343 with chronic obstructive pulmonary disease (COPD) in the Chinese Han population.<h4>Method</h4>We assessed IL-33 rs928413 and rs7044343 polymorphisms by Sanger sequencing of PCR products amplified from the genomic DNA of 160 COPD patients and 123 healthy controls.<h4>Results</h4>There was no significant difference in the distribution of rs928413 AA, AG, or AA genotypes or rs704 ...[more]