Ontology highlight
ABSTRACT:
SUBMITTER: Chambers JM
PROVIDER: S-EPMC7731726 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Chambers Joseph M JM Addiego Amanda A Flores-Mireles Ana L AL Wingert Rebecca A RA
Cell reports 20201101 6
Cilia are microtubule-based organelles that function in a multitude of physiological contexts to perform chemosensing, mechanosensing, and fluid propulsion. The process of ciliogenesis is highly regulated, and disruptions result in disease states termed ciliopathies. Here, we report that peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (ppargc1a) is essential for ciliogenesis in nodal, mono-, and multiciliated cells (MCCs) and for discernment of renal tubule ciliated cell fa ...[more]