Ontology highlight
ABSTRACT: Introduction
In contrast to most colorectal carcinomas arising from pedunculated or sessile protruded adenomas, submucosal-invasive (pT1) colorectal carcinoma exhibiting a depressed surface (hereinafter, "depressed colorectal carcinoma," identified by means of high-definition endoscopy) is considered to be derived from depressed precursors. We hypothesized that depressed colorectal neoplasms have unique clinicopathological features different that are different from those of protruded and flat colorectal neoplasms.Methods
We classified 27,129 colorectal neoplasms (909 pT1 carcinomas and 26,220 adenomas) resected between 2001 and 2017 into depressed (211 carcinomas and 109 adenomas), flat (304 carcinomas and 11,246 adenomas), and protruded subtypes (394 carcinomas and 14,865 adenomas) and compared their clinicopathological features. As exploratory analyses of pT1 carcinomas, we conducted whole-exome sequencing for 19 depressed and 8 protruded subtypes and RNA sequencing for 8 depressed and 8 protruded subtypes.Results
pT1 carcinomas were more common in depressed lesions (66%) than in protruded (2.6%) and flat lesions (2.6%) (P < 0.001). Compared with nondepressed pT1 carcinomas, depressed pT1 carcinomas were positively correlated with lymphovascular invasion, tumor budding, and massive submucosal invasion and inversely correlated with the presence of an adenoma component (all P < 0.001). Depressed adenomas were more likely to contain high-grade dysplasia than nondepressed adenomas (49% vs 11%, P < 0.001). A KRAS mutation was observed only in one of the 19 depressed pT1 carcinomas. Relative to protruded carcinomas, depressed carcinomas generally exhibited higher expression of genes related to angiogenesis and epithelial-mesenchymal transition.Discussion
Depressed colorectal neoplasms may harbor a unique combination of malignant histopathological phenotypes and molecular features.
SUBMITTER: Kudo SE
PROVIDER: S-EPMC7732270 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Kudo Shin-Ei SE Kouyama Yuta Y Ogawa Yushi Y Ichimasa Katsuro K Hamada Tsuyoshi T Kato Kazuki K Kudo Koki K Masuda Takaaki T Otsu Hajime H Misawa Masashi M Mori Yuichi Y Kudo Toyoki T Hayashi Takemasa T Wakamura Kunihiko K Miyachi Hideyuki H Sawada Naruhiko N Sato Toshiro T Shibata Tatsuhiro T Hamatani Shigeharu S Nemoto Tetsuo T Ishida Fumio F Niida Atsushi A Miyano Satoru S Oshima Masanobu M Ogino Shuji S Mimori Koshi K
Clinical and translational gastroenterology 20201201 12
<h4>Introduction</h4>In contrast to most colorectal carcinomas arising from pedunculated or sessile protruded adenomas, submucosal-invasive (pT1) colorectal carcinoma exhibiting a depressed surface (hereinafter, "depressed colorectal carcinoma," identified by means of high-definition endoscopy) is considered to be derived from depressed precursors. We hypothesized that depressed colorectal neoplasms have unique clinicopathological features different that are different from those of protruded and ...[more]