TILRR (FREM1 isoform 2) is a prognostic biomarker correlated with immune infiltration in breast cancer.
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ABSTRACT:
SUBMITTER: Xu XY
PROVIDER: S-EPMC7732299 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
TILRR (FREM1 isoform 2) is a prognostic biomarker correlated with immune infiltration in breast cancer.
Xu Xiao-Yi XY Guo Wen-Jing WJ Pan Shi-Hua SH Zhang Ying Y Gao Feng-Lin FL Wang Jiang-Tao JT Zhang Sheng S Li He-Ying HY Wang Ren R Zhang Xiao X
Aging 20201008 19
In atherosclerosis, upregulated TILRR (FREM1 isoform 2) expression increases immune cell infiltration. We hypothesized that <i>TILRR</i> expression is also correlated with cancer progression. By analyzing data from Oncomine and the Tumor Immune Estimation Resource, we found that <i>TILRR</i> mRNA expression was significantly lower in breast cancer tissue than adjacent normal tissue. Kaplan-Meier survival analysis and immunohistochemical staining revealed shortened overall survival and disease-fr ...[more]
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