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Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report.

ABSTRACT: In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.

SUBMITTER: Cenciarelli S 

PROVIDER: S-EPMC7732473 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report.

Cenciarelli Sabina S   Calbi Valeria V   Barzaghi Federica F   Bernardo Maria Ester ME   Oltolini Chiara C   Migliavacca Maddalena M   Gallo Vera V   Tucci Francesca F   Fraschetta Federico F   Albertazzi Elena E   Fratini Elena Sophia ES   Consiglieri Giulia G   Giannelli Stefania S   Dionisio Francesca F   Sartirana Claudia C   Racca Sara S   Camesasca Chiara C   Peretto Giovanni G   Daverio Rita R   Esposito Antonio A   De Cobelli Francesco F   Silvani Paolo P   Rabusin Marco M   Cara Andrea A   Trabattoni Daria D   Dispinseri Stefania S   Scarlatti Gabriella G   Piemonti Lorenzo L   Lampasona Vito V   Cicalese Maria Pia MP   Aiuti Alessandro A   Ferrua Francesca F  

Frontiers in immunology 20201124

In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and ex  ...[more]

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