Clot Permeability, Agonist Transport, and Platelet Binding Kinetics in Arterial Thrombosis.

ABSTRACT: The formation of wall-adherent platelet aggregates is a critical process in arterial thrombosis. A growing aggregate experiences frictional drag forces exerted on it by fluid moving over or through the aggregate. The magnitude of these forces is strongly influenced by the permeability of the developing aggregate; the permeability depends on the aggregate's porosity. Aggregation is mediated by formation of ensembles of molecular bonds; each bond involves a plasma protein bridging the gap between specific receptors on the surfaces of two different platelets. The ability of the bonds existing at any time to sustain the drag forces on the aggregate determines whether it remains intact or sheds individual platelets or larger fragments (emboli). We investigate platelet aggregation in coronary-si

SUBMITTER: Du J 

PROVIDER: S-EPMC7732729 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature