Ontology highlight
ABSTRACT:
SUBMITTER: Rychel K
PROVIDER: S-EPMC7732839 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Rychel Kevin K Sastry Anand V AV Palsson Bernhard O BO
Nature communications 20201211 1
The transcriptional regulatory network (TRN) of Bacillus subtilis coordinates cellular functions of fundamental interest, including metabolism, biofilm formation, and sporulation. Here, we use unsupervised machine learning to modularize the transcriptome and quantitatively describe regulatory activity under diverse conditions, creating an unbiased summary of gene expression. We obtain 83 independently modulated gene sets that explain most of the variance in expression and demonstrate that 76% of ...[more]