Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis.

ABSTRACT: Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors, leading to a higher risk of negative health-related outcomes. "Inflammaging", an age-related state of low-grade chronic inflammation, is characterized by an increased concentration of pro-inflammatory cytokines and acute phase proteins. Inflammaging has been postulated as an underlying mechanism of frailty, and several studies tested the relationship between frailty and concentration of inflammatory mediators. The aim of this systematic review and meta-analysis was to test whether inflammatory mediators are overproduced in frail older adults. Among the 758 articles identified in the literature search, 50 were included in the systematic review, and 39 in the three meta-analyses, i.e., C-reactive prote

SUBMITTER: Marcos-Perez D 

PROVIDER: S-EPMC7732924 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature