Ontology highlight
ABSTRACT:
SUBMITTER: Schuster A
PROVIDER: S-EPMC7732990 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Nature communications 20201211 1
The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind the blood brain barrier reducing the efficacy of systemic treatment. Here, we use a genome-wide interference screen to determine invasion-essential genes and identify the AN1/A20 zinc finger domain containing protein 3 (ZFAND3) as a crucial driver of GBM invasion. Using patient-derived cellular models, we show that loss of ZFAND3 ham ...[more]