Ontology highlight
ABSTRACT:
SUBMITTER: Yonova-Doing E
PROVIDER: S-EPMC7733496 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Yonova-Doing Ekaterina E Zhao Wanting W Igo Robert P RP Wang Chaolong C Sundaresan Periasamy P Lee Kristine E KE Jun Gyungah R GR Alves Alexessander Couto AC Chai Xiaoran X Chan Anita S Y ASY Lee Mei Chin MC Fong Allan A Tan Ava G AG Khor Chiea Chuen CC Chew Emily Y EY Hysi Pirro G PG Fan Qiao Q Chua Jacqueline J Chung Jaeyoon J Liao Jiemin J Colijn Johanna M JM Burdon Kathryn P KP Fritsche Lars G LG Swift Maria K MK Hilmy Maryam H MH Chee Miao Ling ML Tedja Milly M Bonnemaijer Pieter W M PWM Gupta Preeti P Tan Queenie S QS Li Zheng Z Vithana Eranga N EN Ravindran Ravilla D RD Chee Soon-Phaik SP Shi Yuan Y Liu Wenting W Su Xinyi X Sim Xueling X Shen Yang Y Wang Ya Xing YX Li Hengtong H Tham Yih-Chung YC Teo Yik Ying YY Aung Tin T Small Kerrin S KS Mitchell Paul P Jonas Jost B JB Wong Tien Yin TY Fletcher Astrid E AE Klaver Caroline C W CCW Klein Barbara E K BEK Wang Jie Jin JJ Iyengar Sudha K SK Hammond Christopher J CJ Cheng Ching-Yu CY
Communications biology 20201211 1
Nuclear cataract is the most common type of age-related cataract and a leading cause of blindness worldwide. Age-related nuclear cataract is heritable (h<sup>2</sup> = 0.48), but little is known about specific genetic factors underlying this condition. Here we report findings from the largest to date multi-ethnic meta-analysis of genome-wide association studies (discovery cohort N = 14,151 and replication N = 5299) of the International Cataract Genetics Consortium. We confirmed the known genetic ...[more]