Ontology highlight
ABSTRACT:
SUBMITTER: An S
PROVIDER: S-EPMC7733858 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
An Sugyun S Cho Si-Young SY Kang Junsoo J Lee Soobeom S Kim Hyung-Su HS Min Dae-Jin DJ Son EuiDong E Cho Kwang-Hyun KH
Proceedings of the National Academy of Sciences of the United States of America 20201123 49
Cellular senescence is defined as a stable, persistent arrest of cell proliferation. Here, we examine whether senescent cells can lose senescence hallmarks and reenter a reversible state of cell-cycle arrest (quiescence). We constructed a molecular regulatory network of cellular senescence based on previous experimental evidence. To infer the regulatory logic of the network, we performed phosphoprotein array experiments with normal human dermal fibroblasts and used the data to optimize the regul ...[more]