Ontology highlight
ABSTRACT:
SUBMITTER: Chu L
PROVIDER: S-EPMC7734496 | biostudies-literature | 2020 Jan-Dec
REPOSITORIES: biostudies-literature
Technology in cancer research & treatment 20200101
Periostin (POSTN) is a protein secreted by mesenchymal cells. Periostin is upregulated in several cancer types and overexpression is associated with poor prognosis. However, the functional role and molecular underpinnings of periostin in epithelial ovarian cancer (EOC) is unknown. In the present study, periostin was found to be significantly upregulated in EOC stroma. Functional studies revealed that periostin could decrease cisplatin (DDP)-induced apoptosis in EOC. Periostin led to DDP resistan ...[more]