Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity: a randomized crossover trial

ABSTRACT:

Background

Postprandial glucose, insulin, and triglyceride metabolism is impaired by prolonged sitting, but enhanced by exercise. The aim of this study was to assess the effects of a continuous exercise bout with and without intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides.

Methods

Sedentary adults who were overweight to obese (n?=?67; mean age 67?yr SD?±?7; BMI 31.2?kg?m??2 SD?±?4.1), completed three conditions: SIT: uninterrupted sitting (8-h, control); EX+SIT: sitting (1-h), moderate-intensity walking (30-min), uninterrupted sitting (6.5-h); EX+BR: sitting (1-h), moderate-intensity walking (30-?min), sitting interrupted every 30-min with 3-min of light-intensity walking (6.5?h). Participants consumed standardized breakfast and lunch meals and blood was sampled at 13 time-points.

Results

When compared to SIT, EX+SIT increased total area under the curve (tAUC) for glucose by 2% [0.1–4.1%] and EX+BR by 3% [0.6–4.7%] (all p?Conclusions Additional reductions in postprandial insulin-glucose dynamics and triglycerides may be achieved by combining exercise with breaks in sitting. Relative to uninterrupted sitting, this strategy may reduce postprandial insulin more in those with high basal insulin resistance, but those with high fasting triglycerides may be resistant to such intervention-induced reductions in triglycerides.

Trial registration

Australia New Zealand Clinical Trials Registry (ACTRN12614000737639).

Supplementary Information

The online version contains supplementary material available at 10.1186/s12966-020-01057-9.

SUBMITTER: Wheeler M 

PROVIDER: S-EPMC7734727 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature