Changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with resectable and borderline resectable pancreatic cancer.

ABSTRACT:

Background

Inflammatory nutritional factors, such as the neutrophil/lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS), modified GPS (mGPS), and C-reactive protein/albumin (CRP/Alb) ratio, have prognostic values in many types of cancer. In this study, the prognostic values of inflammatory nutritional scores were evaluated in the patients with resectable or borderline resectable pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant chemoradiotherapy (NACRT).

Methods

A total of 49 patients who underwent pancreatectomy after NACRT from September 2009 to May 2016 were enrolled. The NACRT consisted of hypofractionated external-beam radiotherapy (30 Gy in 10 fractions) with concurrent S-1 (60 mg/m²) delivered 5 days/week for 2 weeks before pancreatectomy. Inflammatory nutritional scores were determined before and after NACRT in this series.

Results

The median NLR increased after NACRT (from 2.067 to 3.302), with statistical difference (p?ConclusionIn addition to pre-NACRT mGPS, ?CRP/Alb after NACRT could provide prognostic value in the patients with PDAC treated by NACRT.

SUBMITTER: Oshima M 

PROVIDER: S-EPMC7734830 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature