Ontology highlight
ABSTRACT:
SUBMITTER: Lin YR
PROVIDER: S-EPMC7735217 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Lin Yu-Ru YR Parks K Rachael KR Weidle Connor C Naidu Anika S AS Khechaduri Arineh A Riker Andrew O AO Takushi Brittany B Chun Jung-Ho JH Borst Andrew J AJ Veesler David D Stuart Andrew A Agrawal Parul P Gray Matthew M Pancera Marie M Huang Po-Ssu PS Stamatatos Leonidas L
Immunity 20201001 4
Activating precursor B cell receptors of HIV-1 broadly neutralizing antibodies requires specifically designed immunogens. Here, we compared the abilities of three such germline-targeting immunogens against the VRC01-class receptors to activate the targeted B cells in transgenic mice expressing the germline VH of the VRC01 antibody but diverse mouse light chains. Immunogen-specific VRC01-like B cells were isolated at different time points after immunization, their VH and VL genes were sequenced, ...[more]