Water-dispersible unadulterated ?-mangostin particles for biomedical applications.

ABSTRACT: ?-Mangostin, the extract from pericarp of Garcinia mangostana L . or mangosteen fruit, has been applied in various biomedical products because of its minimal skin irritation, and prominent anti-inflammatory, antimicrobial and immune-modulating activities. Owing to its low water solubility, the particle formulations are necessary for the applications of ?-mangostin in aqueous media. The particle formulations are usually prepared using surfactants and/or polymers, usually at a larger amount of these auxiliaries than the amount of ?-mangostin itself. Here, we show the self-assembly of ?-mangostin molecules into water-dispersible particles without a need of any polymers/surfactants. Investigations on chemical structure, crystallinity and thermal properties of the obtained ?-mangostin particles, in comparison to the conventional ?-mangostin crystalline solid, confirm no formation of the new compound during the particle formation and suggest changes in intermolecular interactions among ?-mangostin molecules and significantly more hydroxyl functionality positioned at the particles' surface. The ability of the water suspension of the ?-mangostin to inhibit the growth of Propionibacterium acnes, the acne-causing bacteria, is similar to that of the solution of the conventional ?-mangostin in 5% dimethyl sulfoxide. Moreover, at 12.7 ppm in an aqueous environment of RAW 264.7 cell culture, ?-mangostin suspension exhibits five times higher anti-inflammatory activity than the conventional ?-mangostin solution, with the same acceptable cytotoxicity of less than 20% cell death.

SUBMITTER: Bumrung J 

PROVIDER: S-EPMC7735336 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature