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New and Emerging Therapies for Pulmonary Arterial Hypertension.

ABSTRACT: Pulmonary arterial hypertension (PAH) is a pulmonary vasculopathy that causes right ventricular dysfunction and exercise limitation and progresses to death. New findings from translational studies have suggested alternative pathways for treatment. These avenues include sex hormones, genetic abnormalities and DNA damage, elastase inhibition, metabolic dysfunction, cellular therapies, and anti-inflammatory approaches. Both novel and repurposed compounds with rationale from preclinical experimental models and human cells are now in clinical trials in patients with PAH. Findings from these studies will elucidate the pathobiology of PAH and may result in clinically important improvements in outcome.

SUBMITTER: Spiekerkoetter E

PROVIDER: S-EPMC7735523 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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New and Emerging Therapies for Pulmonary Arterial Hypertension.

Spiekerkoetter Edda E Kawut Steven M SM de Jesus Perez Vinicio A VA

Annual review of medicine 20180914

Pulmonary arterial hypertension (PAH) is a pulmonary vasculopathy that causes right ventricular dysfunction and exercise limitation and progresses to death. New findings from translational studies have suggested alternative pathways for treatment. These avenues include sex hormones, genetic abnormalities and DNA damage, elastase inhibition, metabolic dysfunction, cellular therapies, and anti-inflammatory approaches. Both novel and repurposed compounds with rationale from preclinical experimental ...[more]

PMID: 30216732

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2003-11-15 | GSE703 | GEO

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