Ontology highlight
ABSTRACT:
SUBMITTER: Lenz M
PROVIDER: S-EPMC7735586 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Lenz Michael M Schulz Andreas A Koeck Thomas T Rapp Steffen S Nagler Markus M Sauer Madeleine M Eggebrecht Lisa L Ten Cate Vincent V Panova-Noeva Marina M Prochaska Jürgen H JH Lackner Karl J KJ Münzel Thomas T Leineweber Kirsten K Wild Philipp S PS Andrade-Navarro Miguel A MA
PloS one 20201214 12
Targeted proteomics utilizing antibody-based proximity extension assays provides sensitive and highly specific quantifications of plasma protein levels. Multivariate analysis of this data is hampered by frequent missing values (random or left censored), calling for imputation approaches. While appropriate missing-value imputation methods exist, benchmarks of their performance in targeted proteomics data are lacking. Here, we assessed the performance of two methods for imputation of values missin ...[more]