Ontology highlight
ABSTRACT:
SUBMITTER: Mao K
PROVIDER: S-EPMC7735679 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Mao Kai K Breen Peter P Ruvkun Gary G
PLoS biology 20201202 12
RNA interference (RNAi) is an antiviral pathway common to many eukaryotes that detects and cleaves foreign nucleic acids. In mammals, mitochondrially localized proteins such as mitochondrial antiviral signaling (MAVS), retinoic acid-inducible gene I (RIG-I), and melanoma differentiation-associated protein 5 (MDA5) mediate antiviral responses. Here, we report that mitochondrial dysfunction in Caenorhabditis elegans activates RNAi-directed silencing via induction of a pathway homologous to the mam ...[more]