Somatic HOXB13 Expression Correlates with Metastatic Progression in Men with Localized Prostate Cancer Following Radical Prostatectomy.

ABSTRACT:

Background

Homeobox B13 (HOXB13) expression regulates normal prostate development and mutations are associated with prostate cancer (PCa) formation.

Objective

To assess the role of HOXB13 mRNA expression in PCa progression following radical prostatectomy.

Design, setting, and participants

Genome-wide expression profiles were queried from two retrospective prostatectomy cohorts with follow-up data (Mayo Clinic, n=780; Johns Hopkins Medical Institute [JHMI], n=355), and a prospective genomic registry (n=5239).

Outcome measurements and statistical analysis

Multivariable Cox regressions were used to analyze metastasis-free survival (MFS).

Results and limitations

HOXB13 expression in primary PCa increased with increasing tumor grade and with high metastatic p

SUBMITTER: Weiner AB 

PROVIDER: S-EPMC7736205 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature