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Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study.

ABSTRACT: Hypertriglyceridemic waist phenotype (HTWP) and its quantitative indicator, waist circumference-triglyceride index (WTI), are common quantitative indices of visceral obesity and are closely related to metabolic diseases. The purpose of this study was to investigate the relationship between fatty pancreas (FP) and HTWP in China. FP was diagnosed using trans-abdominal ultrasonography in all participants. According to the waist circumference and serum triglyceride levels, the participants were divided into four phenotype groups: normal waist circumference-normal triglyceride, normal waist circumference-elevated triglyceride, elevated waist circumference-normal triglyceride, and elevated waist circumference-elevated triglyceride (indicating HTWP). Clinical characteristics and biochemical indices were compared among the groups. Receiver operating characteristic (ROC) curves were used to evaluate the utility of WTI as a reference factor for FP screening. The HTWP group had a higher prevalence of metabolic syndrome (84.2%), FP (10.4%), fatty liver (64.5%), and hypertension (15.8%) than the other three phenotype groups. The occurrence rate of HTWP and the median WTI were significantly higher in participants with FP than in those without FP (54.7% vs 21.0%, 222?±?135 vs 142?±?141, p?

SUBMITTER: Yu X

PROVIDER: S-EPMC7736283 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study.

Yu Xiaoping X Wang Dan D Xiao Weiming W Shi Xinlin X She Qiang Q Sun Hongguang H Qi Tingyue T Xu Renyan R Li Guiqing G Liu Xinnong X Gong Weijuan W Yan Zhigang Z Ding Yanbing Y Lu Guotao G

Scientific reports 20201214 1

Hypertriglyceridemic waist phenotype (HTWP) and its quantitative indicator, waist circumference-triglyceride index (WTI), are common quantitative indices of visceral obesity and are closely related to metabolic diseases. The purpose of this study was to investigate the relationship between fatty pancreas (FP) and HTWP in China. FP was diagnosed using trans-abdominal ultrasonography in all participants. According to the waist circumference and serum triglyceride levels, the participants were divi ...[more]

PMID: 33318573

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Project description:Background"Hypertriglyceridemic waist" (HTGW) phenotype, an inexpensive early screening tool for detection of individuals at risk for type 2 diabetes and cardiovascular disease was found to be associated with subclinical atherosclerosis in various patient populations such as those with diabetes mellitus, chronic kidney disease, and those infected with human immunodeficiency virus. However, less is known regarding an association between HTGW and subclinical atherosclerosis in the apparently healthy, multiethnic population. Therefore, the aim of the study was to explore the association between HTGW and sub-clinical atherosclerosis in an apparently healthy, multiethnic population; and to investigate whether the effect of HTGW on sub-clinical atherosclerosis persists over and above the traditional atherosclerosis risk factors.MethodsWe studied 809 individuals of Aboriginal, Chinese, European and South Asian origin who were assessed for indices of sub-clinical atherosclerosis (intima-media thickness (IMT), total area and presence of carotid plaques), socio-demographic and lifestyle characteristics, anthropometrics, lipids, glucose, blood pressure, and family history of cardiovascular disease.ResultsWe found that, compared to individuals without HTGW and after adjusting for age, ethnicity, smoking, and physical activity; men and women with HTGW had a significantly higher: IMT (men: B (95%CI?=?0.084 (0.037, 1.133), p?<?0.001; women: B (95%CI)?=?0.041 (0.006, 0.077), p?=?0.020); and total area (men: B (95%CI?=?0.202 (0.058, 0.366), p?=?0.005; women: B (95%CI)?=?0.115 (0.006, 0.235), p?=?0.037). The association between HTGW waist and presence of plaques was significant for men (OR (95%CI)?=?1.904 (1.040, 3.486), p?=?0.037 vs. men without HTGW), but not for women (p?=?0.284). Once analyses were adjusted for additional, traditional risk factors for atherosclerosis, the effect of HTGW on sub-clinical atherosclerosis was no longer significant.ConclusionsIn conclusion, HTGW may serve as an early marker of subclinical atherosclerosis in men and women, irrespective of ethnicity. However, once individuals are assessed for all traditional risk factors for atherosclerosis, the additional assessment for HTGW is not warranted.

Dataset Information

Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study.

Publications

Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study.

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