Gene expression network analysis provides potential targets against SARS-CoV-2.
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ABSTRACT:
SUBMITTER: Hernandez Cordero AI
PROVIDER: S-EPMC7736291 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Gene expression network analysis provides potential targets against SARS-CoV-2.
Hernández Cordero Ana I AI Li Xuan X Yang Chen Xi CX Milne Stephen S Bossé Yohan Y Joubert Philippe P Timens Wim W van den Berge Maarten M Nickle David D Hao Ke K Sin Don D DD
Scientific reports 20201214 1
Cell entry of SARS-CoV-2, the novel coronavirus causing COVID-19, is facilitated by host cell angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). We aimed to identify and characterize genes that are co-expressed with ACE2 and TMPRSS2, and to further explore their biological functions and potential as druggable targets. Using the gene expression profiles of 1,038 lung tissue samples, we performed a weighted gene correlation network analysis (WGCNA) to identify mo ...[more]
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