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Gene expression network analysis provides potential targets against SARS-CoV-2.

ABSTRACT: Cell entry of SARS-CoV-2, the novel coronavirus causing COVID-19, is facilitated by host cell angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). We aimed to identify and characterize genes that are co-expressed with ACE2 and TMPRSS2, and to further explore their biological functions and potential as druggable targets. Using the gene expression profiles of 1,038 lung tissue samples, we performed a weighted gene correlation network analysis (WGCNA) to identify modules of co-expressed genes. We explored the biology of co-expressed genes using bioinformatics databases, and identified known drug-gene interactions. ACE2 was in a module of 681 co-expressed genes; 10 genes with moderate-high correlation with ACE2 (r?>?0.3, FDR?

SUBMITTER: Hernandez Cordero AI

PROVIDER: S-EPMC7736291 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Gene expression network analysis provides potential targets against SARS-CoV-2.

Hernández Cordero Ana I AI Li Xuan X Yang Chen Xi CX Milne Stephen S Bossé Yohan Y Joubert Philippe P Timens Wim W van den Berge Maarten M Nickle David D Hao Ke K Sin Don D DD

Scientific reports 20201214 1

Cell entry of SARS-CoV-2, the novel coronavirus causing COVID-19, is facilitated by host cell angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). We aimed to identify and characterize genes that are co-expressed with ACE2 and TMPRSS2, and to further explore their biological functions and potential as druggable targets. Using the gene expression profiles of 1,038 lung tissue samples, we performed a weighted gene correlation network analysis (WGCNA) to identify mo ...[more]

PMID: 33318519

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