Ontology highlight
ABSTRACT:
SUBMITTER: Pinto B
PROVIDER: S-EPMC7736620 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Pinto Bruno B Morelli Giovanni G Rastogi Mohit M Savardi Annalisa A Fumagalli Amos A Petretto Andrea A Bartolucci Martina M Varea Emilio E Catelani Tiziano T Contestabile Andrea A Perlini Laura E LE Cancedda Laura L
Neuron 20201006 5
Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the hippocampus of the Dp(16) mouse model of DS and DS individuals, we found activated microglia, as assessed by their morphology; activation markers; and, for DS mice, electrophysiological profile. Accordingly, we found ...[more]