Ontology highlight
ABSTRACT:
SUBMITTER: Yang JH
PROVIDER: S-EPMC7736780 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Nucleic acids research 20201201 22
Long noncoding (lnc)RNAs potently regulate gene expression programs in physiology and disease. Here, we describe a key function for lncRNA OIP5-AS1 in myogenesis, the process whereby myoblasts differentiate into myotubes during muscle development and muscle regeneration after injury. In human myoblasts, OIP5-AS1 levels increased robustly early in myogenesis, and its loss attenuated myogenic differentiation and potently reduced the levels of the myogenic transcription factor MEF2C. This effect re ...[more]