Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation.
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ABSTRACT:
SUBMITTER: Dorronsoro A
PROVIDER: S-EPMC7736882 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation.
Dorronsoro Akaitz A Lang Valérie V Ferrin Izaskun I Fernández-Rueda Jon J Zabaleta Lorea L Pérez-Ruiz Estibaliz E Sepúlveda Pilar P Trigueros César C
Scientific reports 20201214 1
Interleukin (IL)-6 is a pleiotropic cytokine involved in the regulation of hematological and immune responses. IL-6 is secreted chiefly by stromal cells, but little is known about its precise role in the homeostasis of human mesenchymal stromal cells (hMSCs) and the role it may play in hMSC-mediated immunoregulation. We studied the role of IL-6 in the biology of bone marrow derived hMSC in vitro by silencing its expression using short hairpin RNA targeting. Our results show that IL-6 is involved ...[more]
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