Ontology highlight
ABSTRACT:
SUBMITTER: Daniel AM
PROVIDER: S-EPMC7736895 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Daniel Alan M AM Rushing Brenda G BG Tapia Menchaca Karla Y KY
Scientific reports 20201214 1
Understanding the emotional reaction to loss, or frustration, is a critical problem for the field of mental health. Animal models of loss have pointed to the opioid system as a nexus of frustration, physical pain, and substance abuse. However, few attempts have been made to connect the results of animal models of loss to human behavior. Allelic differences in the human mu opioid receptor gene, notably the A118G single nucleotide polymorphism, have been linked to individual differences in pain se ...[more]